Publications & Evidence

Clinical Data & References

A curated overview of publicly available publications and abstracts related to ferumoxytol and relevant imaging research.

Disclaimer: Content on this page is provided for informational purposes only and does not constitute medical advice. Please refer to the full prescribing information and applicable local regulations.

Background (public literature)

Superparamagnetic iron oxide nanoparticles (SPIONs): landscape and examples of approved products

Multiple SPION formulations have been investigated in both preclinical and clinical settings, and some have reached commercialization.

Public review literature links growing interest to factors such as increased kidney disease burden and rising demand for diagnostic and therapeutic applications.

Within this broader SPION landscape, Feraheme® (ferumoxytol injection) was approved in the US in 2009 (and later approved in Canada and Europe). Beyond iron-related indications, ferumoxytol has also been explored in research and clinical trials for imaging applications (e.g., as an MRI contrast agent).

Examples of FDA-cleared / clinically approved iron-oxide nanoparticle products mentioned in the review
  • Feraheme®: iron-related indications (ferumoxytol injection)
  • Combidex® (US) / Sinerem® (EU): MRI-related agent
  • Nanotherm® (MagForce): cancer therapy applications
  • Lumirem®: oral gastrointestinal imaging agent

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Key publications

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Research spotlight: ferumoxytol in Alzheimer’s disease (AD) imaging

Ferumoxytol is a superparamagnetic iron oxide nanoparticle (SPION). Beyond its established use as an iron product, researchers are exploring its potential for non-invasive brain imaging—especially for visualizing neuroinflammation and vascular changes associated with dementia.

What researchers are exploring (high level)

  • Use as a contrast agent to map cerebral blood volume (CBV) and detect disease-related inflammation
  • Potential accumulation in immune cells (e.g., microglia) and vessels may enable MRI detection of inflammation and perfusion changes
  • This field remains investigational; long-term brain safety and clinical utility require further evidence

Note: This section is educational and does not imply an approved indication. For clinical use, refer to the approved labeling and prescribing information.

Optional infographic placeholders

Neuroinflammation imaging
Ferumoxytol-enhanced MRI as a potential marker of immune activation (research).
CBV mapping
Quantification of cerebral blood volume and perfusion-related changes (research).
Cell tracking
Labeling cells with ferumoxytol and tracking distribution by MRI (research).
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